Health & Environmental Research Online (HERO)


Print Feedback Export to File
1619833 
Technical Report 
Metabolism of de-ethyl-atrazine, de-isopropyl-atrazine, and hydro-atrazine by the soluble fraction (105,000 g) from goose liver homogenates 
Foster, TS; Khan, SU; Akhtar, MH 
1980 
PESTAB/81/0207 
Agric 
2 
PESTAB. Incubation of de-ethyl-atrazine [2-chloro-4-amino-6-(isopropyl)-s-triazine] and de-isopropyl-atrazine [2-chloro-4-(ethylamino)-6-amino-s-triazine] with the soluble fraction (105000 g) from goose liver homogenates resulted in the formation of the corresponding hydroxy analog. No dealkylation of hydroxy-atrazine [2-hydroxy-4-(ethylamino)-6-(isopropylamino)-s-triazine] occurred when it was incubated with the enzyme preparation. The data suggest that, in the metabolism of atrazine by the soluble fraction from liver homogenates, the formation of 2-hydroxy partially N-dealkylated metabolites occurs by the hydrolysis of the respective 2-chloro analogues rather than by partial N-dealkylation of hydroxy-atrazine. (Author abstract reprinted by permission of the American Chemical Society)