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1619843 
Journal Article 
Microemulsions: evolving technology for cosmetic applications 
Jayakrishan, A; Kalaiarasi, K; Shah, DO 
1983 
0 
Journal of the Society of Cosmetic Chemists
ISSN: 0037-9832 
IPA/85/567023 
Soc 
REF 43 
335-350 
eng 
IPA COPYRIGHT: ASHP The solubilization of hydrocortisone (I) by microemulsions based on the combination of various alcohols, hydrocarbon oils, and surfactants including sodium stearate, sodium myristate, Brij 35 (laureth 23), Arlacel 186 (glyceryl monooleate and propylene glycol), and isopropanol (isopropyl alcohol) was investigated by spectroscopy at room temperature. The alcohols employed were n-butanol (butyl alcohol), n-pentanol (pentyl alcohol), n-hexanol (hexyl alcohol), and n-heptanol (heptyl alcohol). The oils ranged from n-hexane (hexane) to n-hexadecane (hexadecane). Results showed that the solubility of I was adversely effected by an increase in the chain length of the alcohols, while changes in surfactant concentration or chain length, or water-to-oil ratios in the sodium stearate and sodium myristate microemulsions had no significant effect. Microemulsions of I with Brij 35 and Aracel 186 as surfactants and isopropyl alcohol as cosurfactant were stable up to 70DGC without undergoing phase separation. Viscosity data suggested that the microemulsions were of the water-in-oil type. As observed in the case of sodium stearate microemulsions, the solubilization capacity was independent of the oil chain length and water-to-oil ratios. Replacing water by 0.9% sodium chloride solution did not affect the solubility of I in the microemulsions. Possible applications of microemulsions in skin care and cosmetic areas are mentioned. 
Hydrocortisone; microemulsions; stability; Alcohols; hydrocortisone stability; Alcohols; Alcohols; Alcohols; Hexane; Hexadecane; Sodium stearate; surface active agents; Sodium myristate; Glyceryl monooleate; combination; Propylene glycol; combination; Alcohols; Sodium chloride; vehicles; Laureth 23; Emulsions; water-in-oil; micro-; Steroids; microemulsions; hydrocortisone(Steroids; Solubilization; Structure; alcohols; hydrocortisone microemulsions; Hydrocarbons; oils; Concentration; Viscosity; Temperature; Cosmetics; skin; Formulations; Rheology; Hydrophilic-lipophilic balance; Brij 35; Arlacel 186; Isopropanol; n-Butanol; n-Pentanol; n-Hexanol; n-Heptanol; n-Hexane; n-Hexadecane