Comparison of the local anesthetic, quinidine-like and adrenergic beta-blocking activities of five beta-receptor antagonists | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

1619910

Reference Type

Technical Report

Title

Comparison of the local anesthetic, quinidine-like and adrenergic beta-blocking activities of five beta-receptor antagonists

Author(s)

Davis, WG

Year

1970

Publisher

WILDLIFE INTERNATIONAL LTD

Report Number

IPA/71/42190

Volume

Pharm

Issue

REF 13

Language

eng

Abstract

IPA COPYRIGHT: ASHP Propranolol, pronethalol, INPEA (N-isopropyl-p-nitrophenylethanolamine), MJ 1999 (sotalol; 4-(2-isopropylamino-1-hydroxyethyl)methane sulfonanilide) and MJ 1998 (sotalol; 4-(2-methylamino-1-hydroxypropyl)methane sulfonanilide) exhibit local anesthetic activity when assessed by infiltration anesthesia and at motor nerve endings but only propranolol, pronethalol and INPEA exhibit local anesthetic activity on the phrenic motor nerve. All the beta-adrenergic blocking agents exhibit a quinidine-like activity and there appears to be a close correlation between local anesthetic and quinidine-like activities, which cannot be extended to include adrenergic beta-receptor antagonism.

Keywords

Propranolol; anesthetics; effects; Pronethalol; Nitrophenylethanolamine; N-isopropyl-p-; anesthetics; Metalol; Sotalol; sympatholytic agents; beta; Mechanism of action; beta; INPEA; MJ-1999; MJ-1998