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HERO ID
1620274
Reference Type
Technical Report
Title
Investigation of the metabolism of propallylonal (Noctal)
Author(s)
Bayer, KH; Duchstein WD,
Year
1984
Report Number
IPA/85/627143
Volume
Ztg
Issue
REF 12
Page Numbers
1444-1447
Abstract
IPA COPYRIGHT: ASHP Chromatographic and spectrometric procedures were applied in the analysis of propallylonal (Noctal; I) in urine, collected over a period of 7 to 9 days, from human volunteers who received single oral doses of I (200 mg) and in the urine of rats over a period of 48 h, following a dose of 21 mg/kg of I. The 2 compounds found in the biological samples included unchanged I and the metabolite, 5-acetonyl-5-isopropyl-barbituric acid (II). Both compounds together were detected in a concentration of 25% (5.16% of I and 20.49% of II); 75% were probably metabolite conjugates or possibly ring-open compounds after hydrolysis.
Keywords
Propallylonal
;
metabolism
;
humans and rats
;
5-Acetonyl-5-isopropyl-barbituric acid
;
metabolites
;
propallylonal
;
Anxiolytics
;
metabolism
;
propallylonal(Anxiolytics
;
Urine levels
;
metabolites
;
propallylonal metabolites
;
Noctal
;
HUMAN
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