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1620518 
Journal Article 
Transdermal delivery of diclofenac sodium from Pluronic and other conventional formulations 
Mohamed, FA 
1995 
1 
STP Pharma Sciences
ISSN: 1157-1489 
IPA/96/1099216 
T 
REF 18 
456-460 
WOS:A1995TR08500007 
IPA COPYRIGHT: ASHP The transdermal delivery of diclofenac sodium from poloxamer 407 (Pluronic F-127) gels across excised hairless mouse skin was compared with delivery from 3 commercial gel formulations containing diclofenac sodium (Olfen and Rheumaren) or diclofenac diethylamine (Voltaren Emulgel). The skin permeation of diclofenac from poloxamer gel was significantly affected by the concentration of poloxamer. Higher permeation ratios and steady-state fluxes were seen with lower poloxamer concentrations. The addition of 10% isopropyl alcohol to poloxamer gel significantly increased the permeation ratios and permeability coefficients. Reasonable skin permeation was observed with Olfen and Voltaren Emulgel, while lower permeation was observed with Rheumaren. 
Diclofenac sodium; permeation; skin; Diclofenac diethylamine; Poloxamer 407; gels; diclofenac permeation; Alcohols; effects; Anti-inflammatory agents; skin permeation; diclofenac sodium(Anti-inflammatory agents; diclofenac diethylamine(Anti-inflammatory agents; Carriers; Concentration; Excipients; Equivalency; Absorption; percutaneous; Topical preparations; diclofenac sodium(Topical preparations; diclofenac diethylamine(Topical preparations; Olfen; Rheumaren; Voltaren Emulgel; Pluronic F-127