US EPA

1620660 

Journal Article 

The Relative Toxicity of Acetone, Methylalcohol and Their Mixtures: I 

Sklianskaya, RM; Urieva, FE; Mashbitz, LM 

1936 

Yes 

Journal of Industrial Hygiene and Toxicology
ISSN: 0095-9030 

NIOSH/00128208 

18 

2 

106-116 

The cardiotoxic effects of acetone (67641) and methyl-alcohol (67630) were investigated. Frog heart preparations were exposed to various concentrations of acetone, methyl-alcohol, and a mixture of the two. Cardiac activity was determined based on height of the cardiogram for a given period of time multiplied by the number of heart contractions during the same period of time. Acetone concentrations of 1:400 to 1:200 caused a 15 to 20 percent decrease in cardiac activity. Sharp decreases in cardiac activity occurred as acetone concentration increased. Cardiac function was restored when acetone was removed. Complete recovery occurred at acetone concentrations of 2:100. With methyl-alcohol, only slight decreases in cardiac function occurred during the entrance phase, and little or no recovery occurred during the elimination phase. Mixtures of acetone and methyl-alcohol caused concentration dependent reductions in cardiac activity. Inhibition was most marked at concentrations of 2:100 and 3:100. Cardiac function recovered during the elimination phase; however, recovery was slow after exposure to a 3:100 concentration. For the chemicals alone, acetone was a more potent inhibitor than methyl-alcohol. In mixtures, the effects were additive at concentrations of 1:300 and 2:100; the effects were less than additive at lower concentrations. The authors conclude that acetone is a more potent cardiac depressant than methanol. In mixtures, the influence of acetone predominates. 

DCN-116847; Cardiology; Cardiography; Acetones; Chemical analysis; Toxicology; Toxic effects; Chronic toxicity; Animal studies