US EPA

1621437 

Journal Article 

Film coating by hydroxypropyl cellulose in an automatic process. Part II. Evaluation of coating solutions 

Lindberg N-O; Jonsson, E 

1972 

Yes 

Acta Pharmaceutica
ISSN: 1330-0075 

IPA/73/096088 

Suec 

REF 8 

589-594 

eng 

IPA COPYRIGHT: ASHP An attempt to correlate tablet bed temperature with the occurrence of tackiness in the automatic film coating of tablets with hydroxypropyl cellulose (I) (Klucel) is described. Both meprobamate 12 mm. diameter tablets and 8 mm. placebo diameter tablets were coated. Addition of I to ethanol or isopropyl alcohol, produced an increase in equilibrium bed temperature due to the increased viscosity which caused a decrease in the amount of solvent per spray. Fillers that replaced some of the solvent increased the equilibrium temperature when added to the polymer solution. I caused tack during the drying process if plasticizers and/or fillers were not added. Equal parts of chloroform and ethanol as solvent combined with fillers or plasticizers eliminated the tack. There was no correlation between tablet bed temperature and the occurrence of tackiness if spray periods and drying periods were suitable. 

Hydroxypropyl cellulose; coatings; tablets; Tablets; meprobamate; coatings; hydroxypropyl cellulose; Automation; tablets; Temperature; beds; Films; evaluations; Tranquilizers; coatings; Formulations; hydroxypropyl cellulose; Klucel