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1628738 
Journal Article 
An efficient two-step synthesis of 3-amino-1-benzhydrylazetidine 
Li, B; Witt, MF; Brandt, TA; Whritenour, D 
2006 
7 
478-480 
WOS:000239612800020 
A streamlined process for the synthesis of 3-amino-1-benzhydrylazetidine is described. Commercially available 1-benzhydrylazetidin-3-ol was reacted with methanesulfonyl chloride in the presence of triethylamine in acetonitrile, upon quench with water, the mesylate intermediate (3) was isolated by filtration. The wet filter cake was subsequently treated with ammonium hydroxide/isopropanol in a Parr reactor at similar to 70 degrees C. The procedure afforded the titled compound as mono acetate salt in 72-84% yield. 
azetidine; aminolysis; mesylation; 3-amino-1-azetidine; 1-benzhydrylazetidine