US EPA

1629821 

Journal Article 

Evaluating the effect of a mixture of alcohol and acetic acid for otomycosis therapy 

Moghadam, AY; Asadi, MAli; Dehghani, R; Mahmoudabadi, AliZ; Rayegan, F; Hooshyar, H; Khorshidi, A 

2010 

3 

2 

66-70 

WOS:000208161700005 

Introduction and objective: Otomycosis is a fungal
infection of external auditory meatus. The acute form of the disease causes secretion and
pruritus. The usual prescribed medicines for otomycosis are topical clotrimazole 1%, amphotericin
B and otosporin. The aim of the present study was to evaluate the efficacy of treatment with
isopropyl alcohol and acetic acid for otomycosis. Materials and methods: In the present study 910
patients examined and those suspected to have otomycosis referred to medical mycology laboratory
of Golabchi, Kashan. A questionnaire was also filled for each patient. Both direct and culture
examinations were used to confirm otomycosis in the patients. Then the patients were treated with
the mixture of isopropyl alcohol+acetic acid. Results: Out of 910 examined patients, 60 patients
were suspected to have otomycosis and referred to medical mycology lab. Mycological examinations
confirmed otomycosis in 52 patients (86.7%). Most of the patients (78.8%) were cured perfectly
after therapy with the mixture of alcohol and acetic acid. After three weeks, in addition to
elimination of clinical signs further smear showed no sign of disease. However in four patients
there was a relapse of the disease. Conclusion: Due to therapeutic effect of the mixture of
isopropyl alcohol and acetic acid for otomycosis, its low side effects and low rate of relapse,
it is recommended to use this mixture for the treatment of otomycosis. 

Otomycosis; Isopropyl alcohol; Acetic acid; Aspergillus niger