Concise synthesis of beta-blockers (S)-metoprolol and (S)-betaxolol using hydrolytic kinetic resolution | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

1630055

Reference Type

Journal Article

Title

Concise synthesis of beta-blockers (S)-metoprolol and (S)-betaxolol using hydrolytic kinetic resolution

Author(s)

Muthukrishnan, M; Garud, DR; Joshi, RR; Joshi, RA

Year

2007

Is Peer Reviewed?

Journal

Tetrahedron
ISSN: 0040-4020

Volume

Issue

Page Numbers

1872-1876

DOI

10.1016/j.tet.2006.12.016

Web of Science Id

WOS:000244054900016

Abstract

Enantiopure (S)-metoprolol and (S)-betaxolol were prepared
in an extremely simple and practical way using Jacobsen's hydrolytic kinetic resolution of
terminal epoxides in isopropanol. (c) 2007 Elsevier Ltd. All rights reserved.

Keywords

beta-blockers; metoprolol; betaxolol; hydrolytic kinetic resolution