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1630328 
Journal Article 
PHOTOCHEMICAL STABILITY OF BIOLOGICALLY-ACTIVE COMPOUNDS .4. PHOTOCHEMICAL DEGRADATION OF CHLOROQUINE 
Nord, K; Karlsen, J; Tonnesen, HH 
1991 
Yes 
International Journal of Pharmaceutics
ISSN: 0378-5173
EISSN: 1873-3476 
72 
1 
11-18 
WOS:A1991FP57100002 
Chloroquine has been reported to give toxic reactions which
may be ascribed to the photochemical degradation of the substance. The effects of light at
wavelengths of 240-600 nm on solutions of chloroquine in isopropanol, and of light at wavelengths
of 320-600 nm on solutions of chloroquine in buffer solutions were investigated. Seven of the
photochemical decomposition products of chloroquine were isolated and identified by mass-
spectrometry (EI, CI and high-resolution MS) and nuclear magnetic resonance spectroscopy (H-1-
NMR). 
PHOTOCHEMICAL STABILITY; CHLOROQUINE; ANTIMALARIAL