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1632394 
Journal Article 
Determination of metastable zone width for combined anti-solvent/cooling crystallization 
Trifkovic, M; Sheikhzadeh, M; Rohani, S 
2009 
Yes 
Journal of Crystal Growth
ISSN: 0022-0248 
311 
14 
3640-3650 
WOS:000268652400019 
The metastable zone width (MSZW), induction time and primary
nucleation kinetics have been measured and estimated for simultaneous anti-solvent and cooling
crystallization of paracetamol in isopropanol/water solution. ATR-FTIR spectroscopy and laser
back-scattering are used to measure the solute concentration and primary nucleation event,
respectively. Response surface analysis was applied to find the contribution of the
crystallization mechanism on the MSZW and obtain a statistical model for quick estimation of the
MSZW. Two theoretical approaches for the estimation of nucleation rate kinetic parameters from
experimental data are presented. The methods are obtained by modifying the classical Nyvlt's
correlation for simultaneous cooling/anti-solvent crystallizations. The nucleation order n for
primary nucleation was deduced from the slope of a linear plot of log(MSZW) vs. log(cooling and
anti-solvent rates). The induction time was also estimated by changing the classical methods for
combined cooling and anti-solvent crystallization. (C) 2009 Elsevier B.V. All rights reserved. 
Metastable zone width; Crystallization; Cooling; Anti-solvent; Supersaturation; Paracetamol-isopropanol-water