US EPA

1633212 

Journal Article 

Synthesis and determination of acid dissociation constants of some new 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives 

Yuksek, H; Bahceci, S; Ocak, Z; Ozdemir, M; Ocak, M; Ermis, B; Mutlu, T 

2005 

Yes 

Asian Journal of Chemistry
ISSN: 0970-7077
EISSN: 0975-427X 

17 

1 

195-201 

WOS:000228191800025 

Seven new 3-alkyl(aryl)-4-(3-methoxybenzylideneamino) 4,5dihydro-1H-1,2,4-triazol-5-ones (3) were synthesized by the reactions of 3-alkyl(aryl)-4 amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) with 3-methoxybetizaldehyde. The newly synthesized
3 type compounds were titrated potentiometric ally with tetrabutylammonium hydroxide in four
non-aqueous solvents such as methyl alcohol, isopropyl alcohol, t-butyl alcohol and N,N-
dimethylformamide. The half-neutralization potential values and the corresponding pK(a) values
were determined for all compounds in the solvents described above. Thus, the effects of solvents
and molecular structure upon acidity were investigated. In addition, N-acetyl derivatives of 3
type compounds were also prepared. The new synthesized compounds in the study were fully
characterized. 

4,5-dihydro-1H-1,2,4-triazol-5-ones; Schiff base; acetylation; acidity constants; potentiometric titration