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1640379 
Journal Article 
Evaluation of oxidative stress and DNA damage in traffic policemen exposed to vehicle exhaust 
Prasad, BS; Vidyullatha, P; Venkata, RP; Tirumala, VG; Varre, S; Penagaluru, UR; Grover, P; Mundluru, HP; Penagaluru, PR 
2013 
Yes 
Biomarkers
ISSN: 1354-750X
EISSN: 1366-5804 
18 
5 
406-411 
English 
23738842 
WOS:000323085900006 
Abstract Objective: We aimed to study the genotoxic effects in traffic police who are occupationally exposed due to higher free radical generation. Methods: Ambient and breathing zone air samples were analyzed blood samples were collected for analysis of antioxidant enzymes Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and free radicals - nitric oxide (NO) and malondialdehyde (MDA) levels using a spectrophotometer. DNA damage was measured with the comet assay. Results: Higher levels of benzene (BZ), toluene (TOL), carbon monoxide (CO), benzo([a])pyrene (BaP) and sulfur dioxide (SO2) was observed in traffic police. Elevated levels of NO, MDA and comet tail length and lower SOD and GPx levels observed in traffic police. Conclusion: The studied biomarkers, related to oxidative stress and DNA damage positively correlated in traffic police exposed to environmental air pollutants. 
DNA damage; frees radical generation; oxidative stress; traffic police; vehicular pollution