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1645413 
Journal Article 
Dual effects of the substrate and Pterins on the kinetics of CO binding to neuronal nitric oxide synthase: A laser flash photolysis study 
Bengea, SN; Araki, Y; Ito, O; Igarashi, J; Kurokawa, H; Shimizu, T 
2005 
Yes 
Chemistry Letters
ISSN: 0366-7022
EISSN: 1348-0715 
34 
6 
752-753 
WOS:000230232100004 
Derivatives of pterin, an important cofactor for neuronal nitric oxide synthase, markedly changed the kinetics of CO binding to the enzyme-bound heme. In the absence of the substrate, L-Arg, CO binding was dependent on the CO concentration for pterin complexes, whereas in the presence Of L-Arg, it became CO-independent for most pterin complexes. This suggests dual effects of substrate and pterin binding on the kinetics and access of CO to the ligand channel.