Peterffy, E; Baktai, G; Razga, Z; Tiszlavicz, L; Horvath, I
Purpose. Recent reports suggest that the level of nasal nitric oxide (NO) is low in primary ciliary dyskinesia (PCD), however, there is no experience with nasal and/or exhaled NO and exhaled carbon monoxide (CO) in secondary ciliary dyskinesia (SCID). Therefore, we aimed to determine nasal and external NO and CO in children with histologically proven PCD and SCD.
Methods. Nasal and exhaled NO and CO were measured by Logan analyser (LR2000, UK) in three groups of children aged between 76 and 186 months: 1) PCD (n = 7), 2) SCD (n = 5), and 3) healthy controls (n = 7) (clinical evaluation).
Results. On the basis of clinical aspects and nasal NO (nNO) values the PCD group was divided into two subgroups: 1) PCD1 (n = 4): all classical features of primary ciliary dyskinesia and/or Kartagener syndrome, lower than 100 parts per billion (ppb) nNO values, and 2) PCD2 (n = 3): clinically controversial primary ciliary dyskinesia. situs solitus. higher than 100 ppb nNO values. In PCD1, NO and CO results were as follows: external NO (eNO), 2.48 +/- 0.34 ppb; nNO, 39.8 +/- 12.0 ppb; exhaled CO (cCO), 2.15 +/- 0.33 parts per million (ppm); nasal CO (nCO), 1.01 +/- 0.73 unit. In PCD2: eNO. 3.42 +/- 0.55 ppb, nNO, 874.7 +/- 117.1 ppb; eCO, 3.4 +/- 0.94 ppm; nCO, 1.05 +/- 0.40 unit. In SCD: eNO, 7.32 +/- 1.64 ppb. nNO, 622.6 +/- 192.8 ppb eCO, 2.32 +/- 0.25 ppm; nCO, 0.77 +/- 0.22 unit. In healthy controls: eNO, 3.51 +/- 0.36 ppb nNO, 1,047.0 +/- 83.0 ppb; eCO, 3.26 +/- 0.15 ppm; nCO, 0.97 +/- 0.07 unit. (Data are given as mean +/- SEM.)
Conclusions. We found that in one subgroup of PCD patients (PCD I). nNO levels were extremely low with a moderate decrease in eNO concentration. In PCD2. nNO and eNO values were similar to those in the SCD group. Therefore, the clinical relevance of histologically proven primary ciliary dyskinesia with high nasal NO (PCD2). is the subject of further examination.