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1653697 
Journal Article 
Improvement of intestinal motility using S-methylisothiourea in postoperative ileus 
Uenoyama, S; Kobayashi, T; Takeuchi, Y; Yamashita, K; Koide, Y; Kazui, T 
2004 
1 
American Journal of Surgery
ISSN: 0002-9610
EISSN: 1879-1883 
187 
1 
93-97 
English 
14706594 
WOS:000187804000020 
BACKGROUND: The inflammatory mediator nitric oxide (NO) plays an important role in postoperative gastrointestinal motility.

METHODS: Using S-methylisothiourea sulfate (SMT), a selective inducible nitric oxide synthase inhibitor, we studied the physiological role of the endogenous NO in the modulation of intestinal motility. The study was performed in vivo in a canine postoperative model. Ten mongrel dogs were treated with a continuous intravenous infusion of SMT after a surgical intestinal manipulation. Small intestine transit time was fluoroscopically measured using barium sulfate as it passed through a gastrostomy tube on postoperative days (POD) 1, 2, and 3.

RESULTS: Average transit times on POD 1 in the 4 mg/kg/h and 2 mg/kg/h SMT groups significantly decreased compared with that of the saline group. However, the transit times on POD 2 and 3 were not significantly different among the three groups.

CONCLUSIONS: S-methylisothiourea sulfate improves small intestine motility at an early postoperative stage. 
motility; ileus; isothiourea; nitric oxide; dog