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1665255 
Journal Article 
Blockade of hyperalgesia and neurogenic oedema by topical application of nitroglycerin 
Ferreira, SH; Lorenzetti, BB; Faccioli, LH 
1992 
1 
European Journal of Pharmacology
ISSN: 0014-2999
EISSN: 1879-0712 
217 
2-3 
207-209 
English 
1425939 
WOS:A1992JE77800014 
Surprisingly, a single topical application of a nitroglycerin (NTG) gel in humans has been shown to cause analgesia and to reduce oedema in thrombophlebitis. In the present investigation, we showed that the NTG gel reduces prostaglandin E2-induced hyperalgesia and blocks neurogenic inflammation induced in rat skin by antidromic electrical stimulation of the saphenous nerve. These results offer an explanation for the effects of topical application of NTG observed in thrombophlebitis, which may be common to other cutaneous pathologies. The data also support the development of nitrates the effects of which are restricted to the site of application. 
NITRIC OXIDE (NO); HYPERALGESIA; NEUROGENIC EDEMA 
• Nitrate/Nitrite
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