Expression of inducible nitric oxide synthase in duodenal tissue of HIV-infected patients | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

1677368

Reference Type

Journal Article

Title

Expression of inducible nitric oxide synthase in duodenal tissue of HIV-infected patients

Author(s)

Bauer, U; Heise, W; Schmidt, W; Daum, S; Riecken, EO; Ullrich, R

Year

1998

Is Peer Reviewed?

Yes

Journal

Annals of the New York Academy of Sciences
ISSN: 0077-8923
EISSN: 1749-6632

Book Title

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Volume

859

Page Numbers

307-310

PMID

9928410

DOI

10.1111/j.1749-6632.1998.tb11152.x

Web of Science Id

WOS:000077943500046

Abstract

Inducible nitric oxide synthase (iNOS) is an important antimicrobial effector system of rodent macrophages. Human macrophages infected in vitro with M. avium complex (MAC) increased NO2 levels in culture supernatants that could be supressed by NO-synthase inhibitors.(1) However, other investigators found no induction of iNOS in human macrophages by various stimuli.(2,3) Although high levels of NO2 have been found in sera from patients with HIV-infection(4) or with inflammatory bowel disease,(5) the role of iNOS in human macrophages is still unclear. Because intestinal infections are frequent complications in HIV infection, we investigated iNOS mRNA in the duodenal mucosa of HIV-infected patients.