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1690922 
Journal Article 
Relaxation of arterial smooth muscle by water-soluble derivatives of coenzyme Q (ubiquinone) 
Bindu, R; Venkataraman, BV; Rao, AV; Ramasarma, T 
2003 
1 
Indian Journal of Biochemistry and Biophysics
ISSN: 0301-1208
EISSN: 0975-0959 
40 
1 
5-13 
English 
22900285 
WOS:000181299000001 
Treatment of coenzyme Q with ozone, permanganate, and ferrous sulfate in presence of ascorbate or hydrogen peroxide yielded water-soluble degradation products, possibly having truncated side-chain and modified ring.These derivatives, but not the intact lipid-quinone, showed relaxation of phenylephrine-contracted rat arterial rings. Representative samples of these also decreased blood pressure when injected into the femoral vein in the rat.These effects offer an explanation for the hypotensive action of exogenous coenzyme Q regardless of its side-chain length. 
Animals; Arteries/drug effects/physiology; Ascorbic Acid/chemistry; Blood Pressure/drug effects; Ferrous Compounds/chemistry; Hydrogen Peroxide/chemistry; In Vitro Techniques; Manganese Compounds/chemistry; Muscle Relaxation/drug effects; Muscle, Smooth, Vascular/drug effects/physiology; Oxides/chemistry; Ozone/chemistry; Rats, Wistar; Solubility; Structure-Activity Relationship; Ubiquinone/analogs & derivatives/pharmacology; Vasodilation/drug effects; Water/chemistry