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HERO ID
1690922
Reference Type
Journal Article
Title
Relaxation of arterial smooth muscle by water-soluble derivatives of coenzyme Q (ubiquinone)
Author(s)
Bindu, R; Venkataraman, BV; Rao, AV; Ramasarma, T
Year
2003
Is Peer Reviewed?
1
Journal
Indian Journal of Biochemistry and Biophysics
ISSN:
0301-1208
EISSN:
0975-0959
Volume
40
Issue
1
Page Numbers
5-13
Language
English
PMID
22900285
Web of Science Id
WOS:000181299000001
URL
https://www.ncbi.nlm.nih.gov/pubmed/22900285
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Abstract
Treatment of coenzyme Q with ozone, permanganate, and ferrous sulfate in presence of ascorbate or hydrogen peroxide yielded water-soluble degradation products, possibly having truncated side-chain and modified ring.These derivatives, but not the intact lipid-quinone, showed relaxation of phenylephrine-contracted rat arterial rings. Representative samples of these also decreased blood pressure when injected into the femoral vein in the rat.These effects offer an explanation for the hypotensive action of exogenous coenzyme Q regardless of its side-chain length.
Keywords
Animals; Arteries/drug effects/physiology; Ascorbic Acid/chemistry; Blood Pressure/drug effects; Ferrous Compounds/chemistry; Hydrogen Peroxide/chemistry; In Vitro Techniques; Manganese Compounds/chemistry; Muscle Relaxation/drug effects; Muscle, Smooth, Vascular/drug effects/physiology; Oxides/chemistry; Ozone/chemistry; Rats, Wistar; Solubility; Structure-Activity Relationship; Ubiquinone/analogs & derivatives/pharmacology; Vasodilation/drug effects; Water/chemistry
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