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1697843 
Journal Article 
Abstract 
Enhancement of effect of exposure to O3 and NO2 by exercise 
Gardner, DE; Illing, JW; Coffin, DL 
1974 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
29 
1 
129-130 
English 
WOS:A1974T653800144 
is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974
Small laboratory animal models have been widely used by environmental toxicologists to investigate the potential health hazard of air pollutants. With few exceptions, during the exposure to the pollutants the animals were at rest. In the natural environment the population at risk is not always at rest, but in contrast, is frequently active. This study was undertaken to determine if exercise during exposure to a gaseous air pollutant would increase the risk resulting from the inhalation of viable organisms. Two groups of mice were exposed to either 0.3, 0.2 or 0.1 ppm of ozone or 3.0, 2.0 or 1.0 ppm of nitrogen dioxide for 3 hr. One group of animals were at rest while the second was on a newly designed mechanized exercise wheel. After the exposure to the gas the groups were combined and together they were then exposed, while at rest, to an aerosol of viable microorganisms. A significant increase in mortality was noted in the exercise animals as compared to those at rest. 
Thirteenth Annual Meeting of the Society of Toxicology 
Washington, D.C. 
March 10–14, 1974