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HERO ID
1760623
Reference Type
Journal Article
Title
On the benefit of magnetic magnesium nanocarrier in cardiovascular toxicity of aluminum phosphide
Author(s)
Baeeri, M; Shariatpanahi, M; Baghaei, A; Ghasemi-Niri, SF; Mohammadi, H; Mohammadirad, A; Hassani, S; Bayrami, Z; Hosseini, A; Rezayat, SM; Abdollahi, M
Year
2013
Is Peer Reviewed?
1
Journal
Toxicology and Industrial Health
ISSN:
0748-2337
EISSN:
1477-0393
Volume
29
Issue
2
Page Numbers
126-135
Language
English
PMID
22075688
DOI
10.1177/0748233711425074
Web of Science Id
WOS:000315761000004
Abstract
The present study was designed to determine the effect of a new (25)Mg(2+)-carrying nanoparticle ((25)MgPMC16) on energy depletion, oxidative stress, and electrocardiographic (ECG) parameters on heart tissue of the rats poisoned by aluminum phosphide (AlP). (25)MgPMC16 at doses of 0.025, 0.05, and 0.1 median lethal dose (LD50 = 896 mg/kg) was administered intravenously (iv) 30 min after a single intragastric administration of AlP (0.25 LD50). Sodium bicarbonate (Bicarb; 2 mEq/kg, iv) was used as the standard therapy. After anesthesia, the animals were rapidly connected to an electronic cardiovascular monitoring device for monitoring of ECG, blood pressure (BP), and heart rate (HR). Later lipid peroxidation, antioxidant power, ATP/ADP ratio, and Mg concentration in the heart were evaluated. Results indicated that after AlP administration, BP and HR decreased while R-R duration increased. (25)MgPMC16 significantly increased the BP and HR at all doses used. We found a considerable increase in antioxidant power, Mg level in the plasma and the heart and a reduction in lipid peroxidation and ADP/ATP ratio at various doses of (25)MgPMC16, but (25)MgPMC16-0.025 + Bicarb was the most effective combination therapy. The results of this study support that (25)MgPMC16 can increase heart energy by active transport of Mg inside the cardiac cells.(25)MgPMC16 seems ameliorating AlP-induced toxicity and cardiac failure necessitating further studies.
Keywords
Magnetic isotope of Mg; nanoparticle; pesticide; oxidative stress; ATP phosphorylation; aluminium phosphide; mitochondrial toxicity
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