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1761715 
Journal Article 
Photodynamic therapy with aluminum-chloro-phtalocyanine induces necrosis and vascular damage in mice tongue tumors 
Figueiro Longo, JP; Lozzi, SP; Simioni, AR; Morais, PC; Tedesco, AC; Azevedo, RB 
2009 
1 
Journal of Photochemistry and Photobiology B: Biology
ISSN: 1011-1344
EISSN: 1873-2682 
94 
2 
143-146 
19097802 
WOS:000263426400011 
In this paper we describe the efficacy of the liposomal AlClPc (aluminum-chloro-phthalocyanine) formulation in PDT study against Ehrlich tumor cells
proliferation in immunocompetent swiss mice tongue. Experiments were conduced in sixteen tumor
induced mice that were divided in three control groups: (1) tumor without treatment; (2) tumor
with 100 J/cm(2) laser (670 nm) irradiation; and (3) tumor with AlClPc peritumoral injection; and
a PDT experimental group when tumors received AlClPc injection followed by tumor irradiation.
Control groups present similar macroscopically and histological patterns after treatments, while
PDT treatment induced 90% of Ehrlich tumor necrosis after 24 h of one single showing the efficacy
of liposome-AlClPc (aluminum-chloro-phthalocyanine) mediated PDT application, on the treatment of
oral cancer. (C) 2008 Elsevier B.V. All rights reserved. 
Photodynamic therapy; Tongue tumor; Necrosis; Vascular damage