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HERO ID
1762182
Reference Type
Journal Article
Title
The Cytotoxic and Ultrastrctural Perturbations of Aluminum Exposed Nile Catfish with Special Reference to the Mitigating Effect of Vitamin C
Author(s)
Moustafa, GG; Khalil, S; Hussein, MMA; Zeinab, ML
Year
2012
Is Peer Reviewed?
1
Journal
Life Science Journal
ISSN:
1097-8135
Volume
9
Issue
4
Page Numbers
5198-5210
Web of Science Id
WOS:000316686000150
Abstract
The genotoxic parameters are currently among the most
valuable fish biomarkers for environmental risk assessment. So, the present study was directed to
explore the toxic impacts of Aluminum chloride (AlCl3) on DNA damage, apoptosis, antioxidant
status and ultrastructural investigations of Nile catfish. The experiment was carried out on 48
fish that randomly divided into four equal groups with two replicates; the first group exposed to
1/20 LC50 of Al//www.lifesciencesite.com, the second group exposed to the combined doses of AlCl3
(1/20 LC50) and vitamin C (Vit. C) at dose of 5 ppm, the third group exposed to Vit C at the dose
previously mentioned and the fourth group was kept as negative control. The experiment was
terminated after six months where the fish were sacrified and specimens from liver and gills of
all groups were obtained and kept at -20 degrees C till applying the required measurements and
another specimen from the same organs were fixed in 10% neutral -buffered formalin and 3%
glutaraldehyde solution for histopathological examination. The results indicated pronounced
significant increase in malondialdehyde (MDA) concentration and significant decrease in both
reduced glutathione (GSH) concentration and superoxide dismutase (SOD) and catalase (CAT) enzyme
activity. AlCl3 elicited an obvious increase in oxidative DNA damage and frequency of apoptotic
cells, these manifestation were markedly ameliorated in the group exposed to the combined doses
of AlCl3 and Vit C. The ultrastructural histopathological findings proved the aforementioned
results. It could be concluded that AlCl3 elucidated a marked ruinous effects on the oxidative
and genotoxic impacts as well as the histopathological alterations which were alleviated by
Vitamin C. [Gihan G. Moustafa, Samah Khalil; Mohamed M. A. Hussein and Zeinab, M. Labib The
Cytotoxic and Ultrastrctural Perturbations of Aluminum Exposed Fish with Special Reference to the
Mitigating Effect of Vitamin C] Life Sci J 2012; 9(4):5198-5210]. (ISSN:1097-8135).
http://www.lifesciencesite.com. 773
Keywords
Aluminum chloride; Apoptosis; DNA damage; Oxidative stress; Ultrastructural investigations; Vitamin C
Tags
IRIS
•
Formaldehyde [archived]
Nervous system effects
Screened
Title/abstract
Specific to other chemicals
2013 LitSearch
Nervous system effects
WOS
Search Update
Retroactive RIS import
2013
HERO Formaldehyde Nervous System Effects 2013 SearchUpdate
2014
HERO_Formaldehyde_Nervoussystemeffects_SearchUpdate_pid_31_uid_4241 AKScreening
•
IRIS Formaldehyde (Inhalation) [Final 2024]
Literature Indexing
WoS
Literature Identification
Nervous System Effects
Excluded
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