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Citation
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HERO ID
1763069
Reference Type
Technical Report
Title
Diethylene glycol monomethyl ether
Author(s)
Bibra working group
Year
1997
Report Number
RISKLINE/1997070001
Volume
1997
Language
English
URL
http://www.bibra-information.co.uk/profile-417.html
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Abstract
Diethylene glycol monomethyl ether (DEGME) demonstrated a low skin irritancy in a number of species and a low eye irritancy in rabbits. A volunteer study using a DEGME solution did not identify any skin sensitizing potential. In laboratory animals, a low oral, inhalation and dermal toxicity has been demonstrated, with the kidney and liver being the target organs. Rats given repeated oral doses developed kidney and testicular damage and showed effects on the thymus, blood, liver, spleen and pituitary. No signs of toxicity were identified in a repeated inhalation study in rats. Mild liver toxicity and some blood effects were reported in guinea-pigs given multiple dermal doses. DEGME caused blood abnormalities when applied repeatedly to the skin of pregnant rabbits; doses that were not maternally toxic induced foetotoxicity. Oral administration during pregnancy caused foetal toxicity and foetal malformations in rats (even at non-toxic maternal doses) and embryotoxicity in mice. DEGME gave no evidence of mutagenic potential in Salmonella typhimurium bacteria (Ames test).
Keywords
ANIMAL
;
acute toxicity
;
subacute toxicity
;
irritancy
;
genetic toxicity
;
reproductive and developmental tests
;
teratogens
;
embryo-fetal toxicity
;
skin
;
eye
;
respiratory system
;
reproductive system
;
liver
;
spleen
;
endocrine gland
;
urinary tract
;
HUMAN
;
hypersensitivity
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