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1766797 
Journal Article 
Abstract 
Biochemical alterations in rat brain after aluminum exposure: protection with curcumin 
Khanna, P; Nehru, B 
2008 
Yes 
Free Radical Biology and Medicine
ISSN: 0891-5849
EISSN: 1873-4596 
45 
Suppl. 
S105-S105 
English 
WOS:000260867900298 
is part of a larger document 3452652 SFRBM's 15th Annual Meeting: Program and Abstracts
Aluminum is unquestionably neurotoxic in both experimental animals and certain human diseases potentially affecting ionic, cholinergic, and dopaminergic neurotransmission in the central nervous system. the role of oxidative stress in this is a widely discussed phenomenon. the present study was designed to study the role of aluminum in mediating oxidative stress. Furthermore, curcumin was administered as a post treatment to evaluate its potential in aluminum induced neurotoxicity. Al was administered orally at a dose of 100 mg kg-1 day-1 for a period of 8 weeks, whereas curcumin was administered intraperitoneally at a dose of 50 mg kg-1 day-1 on alternate days for a period of 8 weeks. the study was carried out in three regions of the brain, namely cerebral cortex, mid brain and cerebellum. a significant increase in MDA levels, reduced glutathione content and total glutathione content was observed in all the regions of brain. Post treatment with curcumin significantly reduced the MDA levels, reduced and total glutathione content. Significant reduction of SOD and Catalase levels was observed after aluminum exposure. Post treatment with curcumin significantly increased the levels of SOD and Catalase in all the three regions of brain. Marked deterioration in the histoarchitecture of the cellular layers was observed in cerebral cortex and mid brain after aluminum exposure. Curcumin exposed animals showed an improvement in the histoarchitecture of cellular layers in cerebral cortex and midbrain. Our result suggests that the brain exposed with aluminum is associated with the decrease in antioxidative defense status and the supplementation of curcumin may prove helpful in managing the aluminum induced neurological disorders characterized by compromised antioxidative defense systems. 
Oxidative stress; aluminum toxicity; curcumin; lipid peroxidation 
Society for Free Radical Biology and Medicine 15th Annual Meeting 
Indianapolis, IN 
November 19-23, 2008