Biochemical alterations in rat brain after aluminum exposure: protection with curcumin
Khanna, P; Nehru, B
HERO ID
1766797
Reference Type
Journal Article
Subtype
Abstract
Year
2008
Language
English
| HERO ID | 1766797 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 2008 |
| Title | Biochemical alterations in rat brain after aluminum exposure: protection with curcumin |
| Authors | Khanna, P; Nehru, B |
| Journal | Free Radical Biology and Medicine |
| Volume | 45 |
| Issue | Suppl. |
| Page Numbers | S105-S105 |
| Abstract | Aluminum is unquestionably neurotoxic in both experimental animals and certain human diseases potentially affecting ionic, cholinergic, and dopaminergic neurotransmission in the central nervous system. the role of oxidative stress in this is a widely discussed phenomenon. the present study was designed to study the role of aluminum in mediating oxidative stress. Furthermore, curcumin was administered as a post treatment to evaluate its potential in aluminum induced neurotoxicity. Al was administered orally at a dose of 100 mg kg-1 day-1 for a period of 8 weeks, whereas curcumin was administered intraperitoneally at a dose of 50 mg kg-1 day-1 on alternate days for a period of 8 weeks. the study was carried out in three regions of the brain, namely cerebral cortex, mid brain and cerebellum. a significant increase in MDA levels, reduced glutathione content and total glutathione content was observed in all the regions of brain. Post treatment with curcumin significantly reduced the MDA levels, reduced and total glutathione content. Significant reduction of SOD and Catalase levels was observed after aluminum exposure. Post treatment with curcumin significantly increased the levels of SOD and Catalase in all the three regions of brain. Marked deterioration in the histoarchitecture of the cellular layers was observed in cerebral cortex and mid brain after aluminum exposure. Curcumin exposed animals showed an improvement in the histoarchitecture of cellular layers in cerebral cortex and midbrain. Our result suggests that the brain exposed with aluminum is associated with the decrease in antioxidative defense status and the supplementation of curcumin may prove helpful in managing the aluminum induced neurological disorders characterized by compromised antioxidative defense systems. |
| Wosid | WOS:000260867900298 |
| Url | http://www.sciencedirect.com/science/article/pii/S0891584908006278 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Indianapolis, IN |
| Conference Name | Society for Free Radical Biology and Medicine 15th Annual Meeting |
| Conference Date | November 19-23, 2008 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Oxidative stress; aluminum toxicity; curcumin; lipid peroxidation |
| Relationship(s) |
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