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1766875 
Journal Article 
Cell Activation and Function Alteration in Rat Livers Induced by Repeated Aluminum Oxide Nanoparticles Exposure 
Li, XBo; Zheng, Hao; Liu, Ran; Liang, GeYu 
2012 
Yes 
Advanced Materials Research
ISSN: 1022-6680 
Advanced Materials Research 
486 
75-79 
WOS:000312463600016 
Liver is a major target of nanoparticles accumulation. Here
we have analyzed the liver function and activation of liver macrophages, which are sensitive to
alteration of liver internal environment after repeated exposure to aluminum oxide nanoparticles.
Sprague-Dawley rats where intraperitoneally injected very two days for 60 dyas with aluminum
oxide nanoparticles (50mg/kg), non-nano aluminum oxide (50mg/kg) and saline. After 60 days
exposure, the concentrations of alanine aminotransferase and aspartic transaminase in plasma were
significantly higher in nano-aluminum oxide group than non-nano-aluminum oxide and control
groups. The number of ED-1(+) and GFAP(+) cells in liver of nano-aluminum oxide and non-nano-
aluminum oxide groups increased significantly than control group. Compared with non-nano-aluminum
oxide, aluminum oxide nanoparticles display potential adverse effects on the hypatocytes and
biliary tract of rat liver and less stimulus to macrophages in liver than non-nano aluminum
oxide. It is suggested that part aluminum oxide nanoparticles avoided from phagocytosis by liver
macrophages. The effects of aluminum oxide nanoparticles exposure should be assessed for its
potential hepatic toxicology. 
aluminum oxide; nanoparticle; Kupffer cell; liver function test