US EPA

1767940 

Journal Article 

Effectiveness and safety of glycopyrrolate for hyperhidrosis 

Gago Sanchez, AnaI; Arias Rico, Roi; Torres Degayon, V; Albornoz Lopez, R 

2010 

16 

1 

38-41 

WOS:000292962300025 

Objective: To review the efficacy and incidence of adverse
effects of glycopyrrolate (glycopyrronium bromide) solutions for treatment of primary focal
hyperhidrosis in patients who were refractory to other treatments. Methods: This was a
prospective observational study in patients with an essential hyperhidrosis. Study participants
were recruited from a dermatology unit in a third-level hospital in Spain from July 2007 to
January 2008. The pharmacy department prepared glycopyrrolate aqueous solutions of different
strengths (0.5%, 1% and 2%) according to prescribed dosing. The solution of glycopyrrolate was
applied topically once or twice daily to the affected areas. Pharmacists prospectively recorded
the patient's data on a structured data collection sheet. The effectiveness of the solutions was
evaluated following proposed improvement criteria: very bad (grade 0), bad (grade 1), medium
(grade 2), good (grade 3) and very good (grade 4). Results: Twenty-five subjects (aged 39 +/- 10
years) were treated with topical glycopyrrolate. Three patients were excluded because the
solutions were only applied for three weeks or less, and one patient because of communication
difficulty. Thus a total of 21 patients were analysed. After applying topical glycopyrrolate, the
subjective effects were: very good in three patients (14.28%), good in 12 patients (57.14%),
medium in four patients (19.05%), bad in one patient (4.76%) and very bad in one patient (4.76%).
Conclusion: Topical glycopyrrolate is a safe and effective treatment for focal hyperhidrosis
without major adverse effects in patients who were refractory to other treatments, e. g.
botulinum toxin type A, aluminium chloride and sympathectomy. 

Effectiveness; glycopyrrolate; hyperhidrosis; safety