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1779514 
Journal Article 
Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels 
Amoroso, S; Schmid-Antomarchi, H; Fosset, M; Lazdunski, M 
1990 
1 
Science
ISSN: 0036-8075
EISSN: 1095-9203 
247 
4944 
852-854 
English 
2305257 
Sulfonylurea-sensitive adenosine triphosphate (ATP)-regulated potassium (KATP) channels are present in brain cells and play a role in neurosecretion at nerve terminals. KATP channels in substantia nigra, a brain region that shows high sulfonylurea binding, are inactivated by high glucose concentrations and by antidiabetic sulfonylureas and are activated by ATP depletion and anoxia. KATP channel inhibition leads to activation of gamma-aminobutyric acid (GABA) release, whereas KATP channel activation leads to inhibition of GABA release. These channels may be involved in the response of the brain to hyper- and hypoglycemia (in diabetes) and ischemia or anoxia.