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1782300 
Journal Article 
Development of PPO inhibitor-resistant cultures and crops 
Li, XG; Nicholl, D 
2005 
1 
Pest Management Science
ISSN: 1526-498X
EISSN: 1526-4998 
61 
3 
277-285 
15660355 
WOS:000227342100010 
Recent progress in the development of protoporphyrinogen
oxidase (PPO, Protox)(double dagger) inhibitor-resistant plant cell cultures and crops is
reviewed, with emphasis on the molecular and cellular aspects of this topic. PPO herbicide-
resistant maize plants have been reported, along with the isolation of plant PPO genes and the
isolation of herbicide-resistant mutants. At the same time, PPO inhibitor-resistant rice plants
have been developed by expression of the Bacillus subtilis PPO gene via targeting the gene into
either chloroplast or cytoplasm. Other attempts to develop PPO herbicide-resistant plants include
conventional tissue culture methods, expression of modified co-factors of the protoporphyrin IX
binding subunit proteins, over-expression of wild-type plant PPO gene, and engineering of P-450
monooxygenases to degrade the PPO inhibitor. (C) 2005 Society of Chemical Industry. 
Protox; protoporphyrinogen oxidase; PPO; selection marker; herbicide resistance