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1785598 
Journal Article 
Synthesis and characterization of core-shell Fe₃O₄-gold-chitosan nanostructure 
Salehizadeh, H; Hekmatian, E; Sadeghi, M; Kennedy, K 
2012 
Yes 
Journal of Nanobiotechnology
ISSN: 1477-3155 
10 
3 
English 
22221555 
WOS:000300328300001 
BACKGROUND: Fe₃O₄-gold-chitosan core-shell nanostructure can be used in biotechnological and biomedical applications such as magnetic bioseparation, water and wastewater treatment, biodetection and bioimaging, drug delivery, and cancer treatment.

RESULTS: Magnetite nanoparticles with an average size of 9.8 nm in diameter were synthesized using the chemical co-precipitation method. A gold-coated Fe₃O₄ monotonous core-shell nanostructure was produced with an average size of 15 nm in diameter by glucose reduction of Au³⁺ which is then stabilized with a chitosan cross linked by formaldehyde. The results of analyses with X-ray diffraction (XRD), Fourier Transformed Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), and Atomic Force Microscopy (AFM) indicated that the nanoparticles were regularly shaped, and agglomerate-free, with a narrow size distribution.

CONCLUSIONS: A rapid, mild method for synthesizing Fe₃O₄-gold nanoparticles using chitosan was investigated. A magnetic core-shell-chitosan nanocomposite, including both the supermagnetic properties of iron oxide and the optical characteristics of colloidal gold nanoparticles, was synthesized. 
bioseparation; core-shell; Fe3O4-gold-chitosan; hydrogel; magnetic; nanocomposite; nanoparticle