[Studies on the influence of an artifically induced inflammatory reaction by creatinine, urea and guanidine injection (author's transl)] | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

1785746

Reference Type

Journal Article

Title

[Studies on the influence of an artifically induced inflammatory reaction by creatinine, urea and guanidine injection (author's transl)]

Author(s)

Stehle, R; Feyen, H; Hiemeyer, V

Year

1975

Is Peer Reviewed?

Journal

Research in Experimental Medicine
ISSN: 0300-9130

Volume

165

Issue

Page Numbers

19-22

Language

German

PMID

1167293

DOI

10.1007/bf01856444

Abstract

The influence of creatinine, urea and guanidine injection on the course of an artifically induced inflammatory reaction has been studied in rats. The formalin and bolus alba edema served as inflammatory models. It was shown that the inflammatory reaction was not significantly altered by urea. By creatinine, however, the inflammation was diminished. If urea and creatinine were given together the course of the inflammatory reaction was not altered significantly, suggesting an inhibitory interrelation between these two substances. Guanidines showed the strongest inhibiting effect on inflammation. It is discussed that guanidines influence energy availability by inhibition of oxydative phosphorylation.

Keywords

Animals; Creatinine/blood/therapeutic use; Disease Models, Animal; Drug Antagonism; Drug Interactions; Edema/chemically induced/drug therapy; Formaldehyde; Guanidines/therapeutic use; Inflammation/drug therapy; Injections, Intravenous; Time Factors; Urea/blood/therapeutic use; 50-00-0; 57-13-6; 60-27-5

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