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1785948 
Technical Report 
Synthesis of 14C-labelled compounds: I. Synthesis of 2 14C-dinitroso-hexahydropyrimidine 
Braun, H; Bertram, B; Wiessler, M 
1977 
HEEP/79/00311 
13 
3 
375-378 
HEEP COPYRIGHT: BIOL ABS. A convenient procedure to synthesize 2-14C-dinitroso-hexahydropyrimidine (DNHP) is described. The synthesis begins with the condensation of 14C-formaldehyde and propylenediamine-1,3 in benzene with azeotropic removal of water. The resulting bases are isolated from the reaction mixture as hydrochlorides and are nitrosated with sodium nitrite in aqueous medium at a constant pH of 4-5. After column chromatography on Silica gel and recrystallisation from ether 2-14C-dinitroso-hexahydropyrimidine (DNHP) is isolated in 30.7% yield based on 14C-formaldehyde. 
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