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1787499 
Technical Report 
Further observations on the effects of s-triazine derivatives on purine metabollzing enzymes 
Fhaolain, IN; Coughlan, MP 
1978 
PESTAB/79/2159 
J 
9 
PESTAB. Enzymes isolated from turkey livers were assayed for activity in the presence of s-triazine derivatives. Xanthine dehydrogenase was completely inhibited. The derivatives in sequence of most effective to least effective are ammeline ammelide allantoxaidin cyanuric acid melamine. No inhibition was observed for oxonate. The enzymic site of oxidizine substrate interaction, determined by the differential effects of ammelide on NADH oxidoreductase activity, is the molybdenum prosthetic groups. Purification of urate oxidase was not successful using affinity chromatography with oxonate coupled to aminopropyl-Sepharose.