US EPA

1798260 

Journal Article 

Stability of lidocaine hydrochloride in 5% dextrose injection in plastic bags 

Smith, FM; Nuessle, NO 

1981 

Yes 

American Journal of Hospital Pharmacy
ISSN: 0002-9289 

IPA/81/460073 

J 

REF 10 

1745-1747 

English 

IPA COPYRIGHT: ASHP The stability of lidocaine injection mixed with 5% dextrose injection and refrigerated or stored at room temperature was studied. Lidocaine injection was added to 5% dextrose injection to provide 4 mg/ml of lidocaine hydrochloride. Samples were assayed for lidocaine and its degradation product, 2,6-dimethylaniline, after 30, 60, and 120 days of storage at room temperature (30DGC) and refrigerated temperature (4DGC). The analysis was by a stability indicating HPLC method. The degradation product, 2,6-dimethylaniline, was not detected at any assay time at either temperature. No statistically significant loss of lidocaine occurred at either temperature. These results suggest that lidocaine hydrochloride injection is chemically stable for up to 120 days at either 30DGC or 4DGC when mixed with 5% dextrose injection in plastic infusion bags. 

Lidocaine hydrochloride; injections; stability; Cardiac drugs; injections; lidocaine hydrochloride(Cardiac drugs; Stability; injections; Temperature; injections; Plastics; containers; lidocaine hydrochloride; 2; decomposition products; lidocaine hydrochloride