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1805589 
Technical Report 
Toxicology Of 2,4,4'-Trichloro-2'-hydroxydiphenyl Ether 
Lyman, FL; Furia, T 
1968 
NIOSH/00137036 
Papers Presented at the Inter 
245-252 
Toxicological data establishing the safety of 2,4,4'-trichloro-2'-hydroxydiphenyl-ether (3380345) (Irgasan) was presented. Animals and humans were used in the various tests. Sprague-Dawley-rats received various doses of Irgasan by stomach tube. The acute oral median lethal dose (LD50) in rats and mice was found to be about 4,000 milligrams per kilogram (mg/kg). Acute intravenous toxicity was determined from rats injected with Irgasan suspended in triethylene-glycol and water. The intravenous LD50 in rats was found to be 29mg/kg. Acute subcutaneous toxicity was determined from rats injected with Irgasan suspended in ethanol. The acute subcutaneous LD50 in rats was found to be 14,700mg/kg. Acute dermal toxicity was determined from New-Zealand-albino-rabbits to which Irgasan was applied as a slurry to skin. The acute dermal LD50 was found to be at least 9,300mg/kg. Subacute oral toxicity was studied in white-rats by administering various doses of Irgasan by stomach tube for 6 days a week for 4 weeks. The animals were then sacrificed and histopathological examinations were performed. All animals survived doses up to 500mg/kg per day, and 8 out of 10 animals survived 1,000mg/kg per day. Subacute dermal toxicity was studied by applying a 5 percent suspension of Irgasan to the shaved backs of white-rats. No local irritating or systemic toxic effects were found. In an 18 month carcinogenic study, Irgasan was applied as 0.5 and 1.0 percent solutions to a shaved intrascapular region of the mice 3 times weekly. These solutions were not carcinogenic and no abnormalities were noted in body weight, food consumption, behavioral and skin reactions, gross and microscopic pathology, or tumor formation. Fifty human subjects were treated with a 0.5 percent Irgasan solution in a 1 percent soap solution. Irgasan was found not to be a sensitizer and the irritation potential depended on concentration. Tests also showed that Irgasan was not a photosensitizing agent. The authors conclude that Irgasan is not a carcinogen, and that the acute oral LD50 is about 4,000mg/kg. 
DCN-141627; Carcinogenesis; Toxic effects; Metabolism; Physical properties; Analytical methods; Chemical analysis; Toxic materials; Biological effects; Molecular structure; Chemical properties; Laboratory animals