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HERO ID
1834331
Reference Type
Journal Article
Title
Cyclohexyl iodide promoted approach for coumarin analog synthesis using small scaffold
Author(s)
Sharma, D; Reddy, CB; Shil, AK; Saroach, RP; Das, P
Year
2013
Is Peer Reviewed?
1
Journal
Molecular Diversity
ISSN:
1381-1991
EISSN:
1573-501X
Volume
17
Issue
4
Page Numbers
651-659
Language
English
PMID
23868184
DOI
10.1007/s11030-013-9461-y
Web of Science Id
WOS:000325716200003
Abstract
New chemical approaches were adopted for the synthesis of biologically important coumarins utilizing cyclohexane-1,3-dione derivatives as novel scaffold which were prepared from acetone and ethyl acrylate following our previous report. The stepwise strategies of aromatization, dehydrogenation, and demethylative cyclization were followed for coumarins synthesis from cyclohexane-1,3-dione derivatives. This work reports the first time cyclohexyl iodide was used for the demethylative cyclization reaction of [Formula: see text]-diaryl acrylates for 4-arylcoumarins synthesis. Graphical abstract.
Keywords
Coumarins; 4-Arylcoumarins; beta, beta-Diarylation; Cinnamic ester; Solid-supported palladium nano/microparticles
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