Health & Environmental Research Online (HERO)


Print Feedback Export to File
1834331 
Journal Article 
Cyclohexyl iodide promoted approach for coumarin analog synthesis using small scaffold 
Sharma, D; Reddy, CB; Shil, AK; Saroach, RP; Das, P 
2013 
Molecular Diversity
ISSN: 1381-1991
EISSN: 1573-501X 
17 
651-659 
English 
New chemical approaches were adopted for the synthesis of biologically important coumarins utilizing cyclohexane-1,3-dione derivatives as novel scaffold which were prepared from acetone and ethyl acrylate following our previous report. The stepwise strategies of aromatization, dehydrogenation, and demethylative cyclization were followed for coumarins synthesis from cyclohexane-1,3-dione derivatives. This work reports the first time cyclohexyl iodide was used for the demethylative cyclization reaction of [Formula: see text]-diaryl acrylates for 4-arylcoumarins synthesis. Graphical abstract. 
Coumarins; 4-Arylcoumarins; beta, beta-Diarylation; Cinnamic ester; Solid-supported palladium nano/microparticles