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Citation
Tags
HERO ID
1850378
Reference Type
Journal Article
Subtype
Review
Title
Protective effect of sulforaphane against oxidative stress: recent advances
Author(s)
Guerrero-Beltrán, CE; Calderón-Oliver, M; Pedraza-Chaverri, J; Chirino, YI
Year
2012
Is Peer Reviewed?
Yes
Journal
Experimental and Toxicologic Pathology
ISSN:
0940-2993
EISSN:
1618-1433
Volume
64
Issue
5
Page Numbers
503-508
Language
English
PMID
21129940
DOI
10.1016/j.etp.2010.11.005
Abstract
Sulforaphane [1-isothiocyanate-(4R)-(methylsulfinyl)butane] is a natural dietary isothiocyanate produced by the enzymatic action of the myrosinase on glucopharanin, a 4-methylsulfinylbutyl glucosinolate contained in cruciferous vegetables of the genus Brassica such as broccoli, brussel sprouts, and cabbage. Studies on this compound is increasing because its anticarcinogenic and cytoprotective properties in several in vivo experimental paradigms associated with oxidative stress such as focal cerebral ischemia, brain inflammation, intracerebral hemorrhage, ischemia and reperfusion induced acute renal failure, cisplatin induced-nephrotoxicity, streptozotocin-induced diabetes, carbon tetrachloride-induced hepatotoxicity and cardiac ischemia and reperfusion. This protective effect also has been observed in in vitro studies in different cell lines such as human neuroblastoma SH-SY5Y, renal epithelial proximal tubule LLC-PK1 cells and aortic smooth muscle A10 cells. Sulforaphane is considered an indirect antioxidant; this compound is able to induce many cytoprotective proteins, including antioxidant enzymes, through the Nrf2-antioxidant response element pathway. Heme oxygenase-1, NAD(P)H: quinone oxidoreductase, glutathione-S-transferase, gamma-glutamyl cysteine ligase, and glutathione reductase are among the cytoprotective proteins induced by sulforaphane. In conclusion, sulforaphane is a promising antioxidant agent that is effective to attenuate oxidative stress and tissue/cell damage in different in vivo and in vitro experimental paradigms.
Tags
OPPT REs
•
OPPT_Carbon Tetrachloride_F. Human Health
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