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1852466 
Journal Article 
Review 
Chelating agents in root canal treatment: mode of action and indications for their use 
Hulsmann, M; Heckendorff, M; Lennon, A 
2003 
Yes 
International Endodontic Journal
ISSN: 0143-2885
EISSN: 1365-2591 
36 
12 
810-830 
English 
14641420 
WOS:000186871100001 
Chelating agents were introduced into endodontics as an aid for the preparation of narrow and calcified root canals in 1957 by Nygaard-Østby. A liquid solution of ethylenediaminetetraacetic acid (EDTA) was thought to chemically soften the root canal dentine and dissolve the smear layer, as well as to increase dentine permeability. Although the efficacy of EDTA preparations in softening root dentine has been debated, chelator preparations have regained popularity recently. Almost all manufacturers of nickel-titanium instruments recommend their use as a lubricant during rotary root canal preparation. Additionally, a final irrigation of the root canal with 15-17% EDTA solutions to dissolve the smear layer is recommended in many textbooks. This paper reviews the relevant literature on chelating agents, presents an overview of the chemical and pharmacological properties of EDTA preparations and makes recommendations for their clinical use. 
chelators; dentine hardness; dentine permeability; EDTA; root canal treatment; smear layer