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1866847 
Journal Article 
The synthesis of fexofenadine 
Wang Ronggeng; Zhao Yougui; Zhang Guanchao 
2013 
1 
Research on Chemical Intermediates
ISSN: 0922-6168
EISSN: 1568-5675 
39 
5 
2149-2155 
English 
WOS:000317622700022 
This work proposes a new simple route for fexofenadine synthesis with low cost and easily obtainable raw materials. We use benzene and methallyl as starting reactants, applying steps of Friedel-Crafts alkylation reaction, hydrolysis, oxidation, esterification reaction, and reduction reaction to obtain the intermediate product, followed by N-alkylation reaction to obtain 4-{1-hydroxy-4-[4-(hydroxydiphenyl)-piperidine]butyl}-α, α-dimethylbenzene acetate. Then, the final product fexofenadine is obtained upon hydrolysis. In the synthesis process, we constantly optimize the reaction conditions such as reaction time, reaction temperature, solvent selection, and other factors, thus improving the final yield of the target product fexofenadine to 33.51 %. © 2012 Springer Science+Business Media B.V. 
Antihistamine; Antagonist; Intermediates; Synthesis; Fexofenadine; 2-[4-(4-Butyric chloride)-phenyl]-2-methyl propyl acetate; 2-(4-Cyclopropyl carbonyl)-phenyl-2-methyl propionate acid; 4-(4-Chloral-1-carbonyl-butyl)-alpha,alpha-dimethyl phenyl acid ethyl ester; 4-(4-Chloro-1-hydroxyl-butyl)-alpha,alpha-dimethyl ethyl phenyl acetate; 4-{1-Hydroxyl-4-[4-(hydroxyl biphenyl methyl)-1-piperidyl]butyl}-alpha,alpha-dimethyl phenyl acetic acid ethyl ester