US EPA

1871674 

Journal Article 

Review 

Chiral separation using capillary electromigration techniques based on ligand exchange principle 

Zhang, H; Qi, Li; Mao, L; Chen, Yi 

2012 

Yes 

Journal of Separation Science
ISSN: 1615-9306
EISSN: 1615-9314 

35 

10-11 

1236-1248 

English 

22733505 

10.1002/jssc.201200067 

WOS:000305694100006 

Over the last couple of decades, researchers have developed diverse chiral separation methods emerged from a few chiral separation principles. This review article is primarily focused on the application of chiral ligand-exchange (CLE) principle in capillary electromigration techniques, such as capillary electrophoresis (CE) and capillary electrochromatography (CEC). First, the most commonly used CLE-CZE separation mode by using different kinds of central ions, such as Cu(II), Zn(II), borate ion, and other metal ions, has been introduced. Meanwhile, several kinds of surfactants have been applied as the micelle-forming agents in the CLE micellar electrokinetic chromatography mode. The highlight of recent research of CLE-CEC is the exploitation of novel columns for chiral separation. Then, two kinds of capillary columns, packed capillary and monolithic capillary column, have been briefly described. Finally, the effective application of these chiral separation methods has been presented, including the application in life science and food analysis area. 

Capillary electrochromatography; Central ion; Chiral ligand exchange capillary electrophoresis; Ligand; Micellar electrokinetic chromatography