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1875625 
Journal Article 
Removal of Nickel by Chelating Drugs from the Organs of Nickel Poisoned Rats 
Dwivedi, PP; Athar, M; Hasan, SK; Srivastava, RC 
1986 
Yes 
Chemosphere
ISSN: 0045-6535
EISSN: 1879-1298 
NIOSH/00165143 
15 
6 
813-821 
The effect of some polyaminocarboxylic acids on nickel (7440020) removal from body organs was examined. The chelating drugs examined included ethylenediamine-tetraacetic-acid (EDTA), 1,2-cyclohexylenediamine-tetraacetic-acid (CDTA), diethylenetriamine-pentaacetic-acid (DTPA), hydroxyethylenediamine-triacetic-acid (HEDTA), and triethylenetetraamine-hexaacetic acid (TTHA). Male albino-rats were used for the study with 66 percent of them receiving partial hepatectomies and the others receiving sham operations. Single subcutaneous injection of nickel-chloride (7718549) were given to the rats immediately following the operation. Chelating drugs were administered 30 minutes after nickel administration. Partial hepatectomy did not alter the distribution of nickel in rats between the liver, kidney, heart and lung at 72 hours after administration. Nickel burden in all four organs was diminished after administration of the chelating agents, with the kidney showing the greatest reduction. The decrease in nickel content suggests the formation of stable and excretable complexes. A higher degree of efficiency in removing nickel from the organs was obtained with EDTA, CDTA, and HEDTA. The suggestion was made that these agents might be useful in medical treatment in early nickel poisoning.