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1937675 
Journal Article 
Abstract 
Embryo-toxicity and fetotoxicity of inhaled carbon-tetrachloride, 1,1-dichloroethane and methyl ethyl ketone in rats 
Leong, BKJ; Schwetz, BA; Gehring, PJ 
1974 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS 
SAN DIEGO 
29 
1 
123 
English 
WOS:A1974T653800128 
is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974
The effects of subanesthetic concentrations of carbon tetrachloride (300 and 1000 ppm), 1,1-dichloroethane (3800 and 6000 ppm) and methyl ethyl ketone (1000 and 3000 ppm) on rat embryonal and fetal development have been studied. Groups of pregnant Sprague-Dawley rats were exposed to each solvent 7 hr/day on days 6 through 15 of gestation. All 3 solvents caused some degree of retarded fetal development, such as delayed ossification of sternebrae. Methyl ethyl ketone caused, in addition to the aforementioned embryotoxicity, a low incidence of true terata (acaudia, imperforate anus and brachygnathia) at 3000 ppm. These studies did not reveal a correlation between the toxicity incurred by the mother exposed to these solvents and that incurred by the embryos or fetuses. 
Hydrocarbons, Chlorinated; Ketones; Solvents; Alanine Transaminase; EC 2.6.1.2; L99N5N533T; Index Medicus; Abnormalities, Drug-Induced -- etiology; Chemical and Drug Induced Liver Injury -- enzymology; Solvents -- poisoning; Alanine Transaminase -- blood; Organ Size; Pregnancy; Animals; Liver -- drug effects; Time Factors; Eating -- drug effects; Ethane -- poisoning; Embryo, Mammalian -- drug effects; Fetus -- drug effects; Hydrocarbons, Chlorinated -- poisoning; Carbon Tetrachloride Poisoning; Ketones -- poisoning 
Thirteenth Annual Meeting of the Society of Toxicology 
Washington, D.C. 
March 10–14, 1974