The kinetics of dissociation of the first oxygen molecule from fully saturated oxyhaemoglobin in sheep blood solutions | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

193941

Reference Type

Journal Article

Title

The kinetics of dissociation of the first oxygen molecule from fully saturated oxyhaemoglobin in sheep blood solutions

Author(s)

Gibson, QH; Roughton, FJ

Year

1955

Is Peer Reviewed?

Journal

Proceedings of the Royal Society: Biological Sciences
ISSN: 0962-8452
EISSN: 1471-2954

Report Number

NIOSH/00005788

Volume

912

Page Numbers

143

Abstract

Description the kinetics of dissociation of the first oxygen molecule from fully saturated oxyhemoglobin in sheep blood solutions. Details are given of a stopped flow apparatus suitable for measuring the rates of the rapid reactions of hemoglobin with oxygen and carbon-monoxide. Measurements are made of the overall velocity constants of combination of oxygen and of carbon-monoxide with sheep hemoglobin, and of the overall rate of dissociation of sheep oxyhemoglobin in the presence of sodium-hydrosulfite. The effect of p-chloromercuribenzoate on velocity constants is also discussed.