A-102395, a new inhibitor of bacterial translocase I, produced by Amycolatopsis sp. SANK 60206 | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

1941436

Reference Type

Journal Article

Title

A-102395, a new inhibitor of bacterial translocase I, produced by Amycolatopsis sp. SANK 60206

Author(s)

Murakami, R; Fujita, Y; Kizuka, M; Kagawa, T; Muramatsu, Y; Miyakoshi, S; Takatsu, T; Inukai, M

Year

2007

Is Peer Reviewed?

Yes

Journal

Journal of Antibiotics
ISSN: 0021-8820

Volume

Issue

Page Numbers

690-695

Language

English

PMID

18057698

DOI

10.1038/ja.2007.88

Web of Science Id

WOS:000251402500004

URL

https://www.proquest.com/scholarly-journals/102395-new-inhibitor-bacterial-translocase-i/docview/1787805889/se-2?accountid=171501
Exit

Abstract

Bacterial phospho-N-acetylmuramyl-pentapeptide translocase (translocase I: EC 2.7.8.13) is a key enzyme in peptidoglycan biosynthesis, and a known target of antibiotics. Here we report a new nucleoside inhibitor for translocase I, A-102395, isolated from the culture broth of the strain Amycolatopsis sp. SANK 60206. A-102395 is a new derivative of capuramycin that has the benzene with a uniquely substituted chain instead of an aminocaprolactam. A-102395 is a potent inhibitor of bacterial translocase I with IC50 value of 11 nM, but possesses no antimicrobial activity against various strains tested.

Keywords

translocase I; peptidoglycan; nucleoside inhibitor; capuramycin; Amycolatopsis sp.; antimicrobial activity