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1947205 
Journal Article 
Microwave-Assisted Domino Hydroformylation without Syngas 
Cini, E; Airiau, E; Girard, N; Mann, A; Salvadori, J; Taddei, M 
2011 
1 
Synlett
ISSN: 0936-5214
EISSN: 1437-2096 
2 
199-202 
WOS:000286176900011 
Hydroformylation is a powerful reaction that has suffered for some negative prejudices related to the use of gaseous H-2 and CO. Now it is possible to carry out hydroformylation and different cyclohydrocarbonylations, even on complex substrates, using aqueous formalin as H-2 and CO surrogate in few minutes under microwave irradiation. The catalytic system developed by Morimoto (Rh/BINAP for decomposition of formaldehyde and Rh/Xantphos for hydroformylation) is compatible with microwave dielectric heating and with complex substrates containing ligand atoms allowing rapid domino hydroformylation cyclization reactions without using the external supply of gaseous H-2 and CO (gas cylinder) and without any particular safety limitation or device. 
microwaves; hydroformylation; homogeneous catalysis; domino reactions