Influence of silver nanoparticles on neurons and blood-brain barrier via subcutaneous injection in rats | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

195575

Reference Type

Journal Article

Title

Influence of silver nanoparticles on neurons and blood-brain barrier via subcutaneous injection in rats

Author(s)

Tang, J; Xiong, L; Wang, S; Wang, J; Liu, L; Li, J; Wan, Z; Xi, T

Year

2008

Is Peer Reviewed?

Yes

Journal

Applied Surface Science
ISSN: 0169-4332

Volume

255

Issue

Page Numbers

502-504

DOI

10.1016/j.apsusc.2008.06.058

Web of Science Id

WOS:000260510600069

Abstract

Nanosilver has been widely used in medical biology; however, the distribution and interaction of nanosilver with cells is still unclear. There have been some reports demonstrating that nanoparticles can cross the blood-brain barrier (BBB). The present study investigated the accumulation of silver nanoparticles in the brain, and the effects of silver nanoparticles on BBB. Nanosilver and microsilver (62.8 mg/kg) particles were subcutaneously injected into rats. The rats were sacrificed at predetermined time points and the brains were obtained for ultrastructural observation and silver level detection. The results showed that silver nanoparticles could traverse the BBB and move into the brain in the form of particle. The silver nanoparticles can induce neuronal degeneration and necrosis by accumulating in the brain over a long period of time.

Keywords

Silver nanoparticle; Distribution; ICP–MS