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195912 
Journal Article 
Determination of 1,4-dioxane in cosmetic products by high-performance liquid chromatography 
Scalia, S; Guarneri, M; Menegatti, E 
1990 
1 
Analyst
ISSN: 0003-2654
EISSN: 1364-5528 
115 
7 
929-931 
English 
2221400 
WOS:A1990DQ75800012 
A rapid high-performance liquid chromatographic procedure has been developed for the assay of 1,4-dioxane in cosmetic products. After solid-phase extraction, using Bond Elut CN and Bond Elut C18 cartridges, samples were analysed directly on a LiChrospher CH-8 reversed-phase column with spectrophotometric detection at 200 nm and acetonitrile - water as eluent. Recovery of 1,4-dioxane from different cosmetic matrices was between 81.5 and 90.1% in the 30-90 microgram g(-1) range. The minimum quantifiable amount was 6.5 microgram g(-1). The method is simple, reproducible and specific and is suitable for routine analyses of commercial cosmetics. 
liquid chromatography chemical analysis 
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• OPPT_1,4-Dioxane_D. Exposure
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