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Citation
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HERO ID
196119
Reference Type
Journal Article
Subtype
Review
Title
Nanosilver: A nanoproduct in medical application
Author(s)
Chen, XS; Schluesener, HJ
Year
2008
Is Peer Reviewed?
1
Journal
Toxicology Letters
ISSN:
0378-4274
EISSN:
1879-3169
Volume
176
Issue
1
Page Numbers
1-12
Language
English
PMID
18022772
DOI
10.1016/j.toxlet.2007.10.004
Web of Science Id
WOS:000252680800001
Abstract
Nanotechnology is a most promising field for generating new applications in medicine. However, only few nanoproducts are currently in use for medical purposes. A most prominent nanoproduct is nanosilver. Nanosilver particles are generally smaller than 100 nm and contain 20?15,000 silver atoms. At nanoscale, silver exhibits remarkably unusual physical, chemical and biological properties. Due to its strong antibacterial activity, nanosilver coatings are used on various textiles but as well as coatings on certain implants. Further, nanosilver is used for treatment of wounds and burns or as a contraceptive and marketed as a water disinfectant and room spray. Thus, use of nanosilver is becoming more and more widespread in medicine and related applications and due to increasing exposure toxicological and environmental issues need to be raised. In sharp contrast to the attention paid to new applications of nanosilver, few studies provide only scant insights into the interaction of nanosilver particle with the human body after entering via different portals. Biodistribution, organ accumulation, degradation, possible adverse effects and toxicity are only slowly recognized and this review is focusing on major questions associated with the increased medical use of nanosilver and related nanomaterials.
Keywords
Silver; Nanoparticles; Rout of entry; Toxicity; Mechanism
Tags
•
Nanoscale Silver
External Review Draft
Final Case Study
Introduction to Document, Silver and Nanoscale Silver
Exposure, Uptake and Dose
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