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HERO ID
197490
Reference Type
Journal Article
Title
Serum dioxin concentrations and age at menarche
Author(s)
Warner, M; Samuels, S; Mocarelli, P; Gerthoux, PM; Needham, L; Patterson, DG, Jr; Eskenazi, B
Year
2004
Is Peer Reviewed?
Yes
Journal
Environmental Health Perspectives
ISSN:
0091-6765
EISSN:
1552-9924
Volume
112
Issue
13
Page Numbers
1289-1292
Language
English
PMID
15345341
DOI
10.1289/ehp.7004
Web of Science Id
WOS:000224547000028
Abstract
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a widespread environmental contaminant, is associated
with delays in pubertal development in animal studies. On 10 July 1976, as a result of a
chemical explosion, residents of Seveso, Italy, experienced the highest levels of TCDD exposure
experienced by a human population. Twenty years later, we initiated the Seveso Women?s Health
Study (SWHS), a retrospective cohort study of female residents of the most contaminated areas, to
determine whether the women were at higher risk for reproductive disease. We examined the association
of TCDD serum levels, based on measurements in serum collected soon after the explosion,
with reported age at menarche among the 282 SWHS women who were premenarcheal at
the time of the explosion. We found no change in risk of onset of menarche with a 10-fold
increase in TCDD (e.g., 10?100 ppt; hazard ratio = 0.95; 95% confidence interval, 0.83?1.09;
p-value for trend = 0.46). When TCDD levels were categorized, there was also no evidence of a
dose?response trend (p = 0.65). In summary, we found that individual serum TCDD measurements
are not significantly related to age at menarche among women in the SWHS cohort. The
women in this study experienced substantial TCDD exposure during the postnatal but prepubertal
developmental period. Given that animal evidence suggests in utero exposure has the most significant
effect on onset of puberty, continued follow-up of the offspring of the SWHS cohort is
important.
Keywords
dioxin; endocrine disruptors; environmental exposures; epidemiology;
menarche; puberty; 2,3,7,8-tetrachlorodibenzo-p-dioxin
EPub Date
06/10/2004
Publication Date
06/10/2004
Tags
IRIS
•
Dioxin (2012 Project Page for Final Report)
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